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This review explores the evidence for materno foetal transmission of HBV in SSA, outlining current practice for HBV MFT prevention and identifying the significant challenges to implementation of HBV prevention in SSA.

These guidelines provide evidence based guidance on the use of peripartum antiviral prophylaxis in HBsAg positive pregnant women for the prevention of mother to child transmission of HBV.

Perinatal transmission of HBV infection is preventable. Vaccination is the best way to prevent HBV infection. When a pregnant patient has HBV infection, it can pose a serious risk to their infant at birth. Infants with HBV infection have about a 90% chance of developing a chronic HBV infection.

In this article, we review the most important routes of transmission in endemic areas for HBV infection and the strategies to prevent vertical transmission. The transmission of infections from mother to offspring is traditionally known as perinatal infection.

After birth, children should take preventive measures, namely regular injections of the hepatitis B vaccine and hepatitis B immunoglobulin (HBIG). The use of antiviral drugs during pregnancy and the injection of the hepatitis B vaccine and HBIG into the newborn greatly reduce the failure rate of HBV MTCT.

Par conséquent, la prévention de ces infections dues à une transmission de la mère à l’enfant ou au cours de la petite enfance est la stratégie la plus importante pour lutter contre l’épidémie d’infection par le VHB.

The identification of hepatitis B infected individuals, coupled with antenatal maternal antiviral prophylaxis and immunoprophylaxis of infants, serve as cornerstone preventive strategies integral to guide elimination of HBV MTCT, though their implementations and successes vary across regions.

Timely HBV vaccination series administered soon after birth might be the mainstay of prevention. This review aimed to provide a concise update on the effectiveness of available strategies to prevent MTCT of HBV.

The birth dose of hepatitis B vaccine constitutes post exposure prophylaxis to prevent transmission to infants exposed to HBV during birth and initiates the first dose of a series of immunizations that will confer long term protection against HBV infection.

The maternal and fetal T cell immunity in HBV infection is important because adaptive immune responses, especially virus specific CD8 T cell responses, are largely responsible for viral clearance and disease pathogenesis during HBV infection.

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